Name | 2-(difluoromethoxy)aniline |
Synonyms | AKOS BB-8570 AKOS B014397 ASISCHEM Y89474 TIMTEC-BB SBB003980 O-DIFLUOROMETHOXYANILINE 2-(DIFLUOROMETHOXY)ANILINE 2-(difluoromethoxy)aniline 2-DIFLUOROMETHOXY-PHENYLAMINE |
CAS | 22236-04-0 |
EINECS | 626-043-0 |
InChI | InChI=1/C7H7F2NO/c8-7(9)11-6-4-2-1-3-5(6)10/h1-4,7H,10H2 |
Molecular Formula | C7H7F2NO |
Molar Mass | 159.13 |
Density | 1.272g/mLat 25°C(lit.) |
Boling Point | 205°C(lit.) |
Flash Point | 199°F |
Vapor Presure | 0.199mmHg at 25°C |
Appearance | Crystallization |
Specific Gravity | 1.272 |
BRN | 2718520 |
pKa | 2.93±0.10(Predicted) |
Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
Refractive Index | n20/D 1.505(lit.) |
MDL | MFCD00190104 |
Risk Codes | 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | 36 - Wear suitable protective clothing. |
UN IDs | 2811 |
WGK Germany | 3 |
HS Code | 29222990 |
Hazard Note | Toxic |
Hazard Class | 6.1 |
Packing Group | III |
application | 2-(difluoromethoxy) aniline can be used as an intermediate in organic synthesis and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical medicine generation process. |
Preparation | Iron powder (5 equivalents) is added to a solution of 2-(difluoromethoxy) nitrobenzene (1 equivalent) in MeOH/MeCOOH(1:1). The reaction mixture was heated at 50°C for 3 hours under N2. Vacuum concentration of the reaction mixture. Add EtOAc (100mL) and 1m NaOH (50mL) to the residue. The precipitate was removed by centrifugation. Separate the water layer. The water layer was extracted with EtOAc (3 × 50 mL). Combine organic layers and extracts. The combined organic layer was dried and extracted with MgSO 4 . Filter the combined organic layer and extract. Vacuum concentration of the combined organic layer and extract. |